Ph.D. in Anthropobiology, University of Toulouse III
Postdoc in Genetics and Epigenetics of Human populations
Contact : firstname.lastname@example.org
Nicolas Brucato is an anthropological geneticist and epigeneticist focusing his research on past and present gene flow between human populations considering the impact of the environment. More specifically he is interested in the genome plasticity occurring after drastic environmental changes and/or admixture events, with a particular focus on genes of the immune system and neurogenesis.
He is part of the OCEOADAPTO ANR project led by Dr Ricaut. He is working on major human migrations between East Africa and Island Southeast Asia. His current research encompasses notably the exploration of the Austronesian dispersal and the genetic legacy of the Swahili kingdoms using genetic and epigenetic markers.
He conducted several studies on diverse major human migrations such as the African Diaspora, the Austronesian expansion in the Indian Ocean or the European Neolithic settlement. In parallel, he studied the genetic and epigenetic factors that influenced the human brain asymmetry, an important developmental factor regarding human cognition and human diseases.
16 peer-reviewed publications, 3 book chapters, 10 oral presentations. Five selected publications :
Kusuma P., Brucato N., Cox M.P., Pierron D., Razafindrazaka H., Adelaar A., Sudoyo H., Letellier T., Ricaut F-X. 2016 Contrasting Linguistic and Genetic Origins of the Asian Source Populations of Malagasy. In press. Scientific Report
Kusuma P., Cox M.P., Pierron D., Razafindrazaka H., Brucato N., Tonasso L., Suryadi H.L., Letellier T., Sudoyo H., Ricaut F-X. 2015 Mitochondrial DNA and the Y chromosome suggest the settlement of Madagascar by Indonesian sea nomad populations. BMC Genomics. 16:191.
Brucato N., DeLisi L.E., Fisher S.E., Francks C. 2014 Hypomethylation of the paternally inherited LRRTM1 promoter linked to schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 165B(7):555-63.
Lacan M., Keyser C., Ricaut F.-X., Brucato N., Duranthon F., Guilaine J., Crubézy E., Ludes B. 2011 Ancient DNA reveals male diffusion through the Neolithic Mediterranean route. Proceedings of the National Academy of Sciences of the United States of America, 108, 9788-9791.
Brucato N., Cassar O., Tonasso L., Guitard E., Migot-Nabias F., Tortevoye P., Plancoulaine S., Larrouy G., Gessain A., Dugoujon J-M. 2010 The imprint of the Slave Trade on an African American population : mitochondrial DNA, Y chromosome and HTLV-1 analysis on the Noir Marron in French Guiana. BMC Evolutionary Biology 10:314.