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Orlando Ludovic


Prof Ludovic Orlando, PhD, HDR

Skype : lorlando1369 | Twitter : LudovicLorlando
Researcher ID A-8932-2013
Orcid ID : 0000-0003-3936-1850
Google Scholar

@Univ. of Toulouse, France :
Laboratoire AMIS CNRS UMR 5288, Faculté de Médecine de Purpan-37 allées Jules Guesde, Bâtiment A, 31000 Toulouse, France
Phone : +33 6 74 38 38 15
Email :

@Univ. of Copenhagen, Denmark :
Centre for GeoGenetics, Natural History Museum of Denmark
Øster Voldgade 5-7, 1350K Copenhagen, Denmark
Phone : +45 353 21 231
Email :

Credit: Nicola Lo Calzo

Biosketch (for media) FullCV
Ludovic Orlando is a former student from the Ecole Normale Superieure of Lyon (ENS, 1996-2000), one of the top-5 French universities. First trained as a molecular biologist, he got increasingly interested in computational biology applied to DNA sequence data. He graduated in molecular genetics from the Univ. of Lyon, France in 2003, twenty years after the first ancient DNA molecule was ever sequenced. Trained in phylogenomics as a postdoc (CNRS EA 3781), he was soon after appointed as a permanent Associate Professor at ENS Lyon, where he lectured and performed research between 2005 and 2010. He started his own research group in 2010 at the Centre for GeoGenetics, Univ. of Copenhagen, Denmark, where he has been appointed as a full Professor in Molecular Archaeology since 2016. He was appointed as a CNRS research director the same year. Amongst his early career achievements feature (1) the sequencing of the oldest genome, (2) the characterization of the first ancient epigenome, and (3) the reconstruction of the genomic history of horse domestication.

Ludovic is the Deputy Director of the Laboratory of Anthropo-Biology (CNRS UMR 5288), and the co-head of the CNRS AMADEUS LIA (International Associated Laboratory), which supports collaborative research programmes with the Centre for GeoGenetics, Univ. of Copenhagen, Denmark. He has been part of several organizing and scientific boards of international meetings, including the prestigious international meeting for the Society of Molecular Biology and Evolution, the International Symposium on Biomolecular Archaeology, the International Union for Quaternary Research and the International Union of the Protohistoric and Prehistoric Sciences. He is a member of the scientific committee of the TAKH Association, aimed at conservation of the Przewalski’s horse in its native Mongolian range. He has been acting as an Academic Editor for the journal PLoS One since January 2012, for Scientific Reports since September 2016, and for Peer J since April 2017. He is one of the four Editors-in-Chief for the journal STAR aimed at promoting innovative approaches in archaeological research. He was expert member of the committee of the French National Research Agency (ANR) in 2012 and 2013, an expert member of the Junior Committee of the ‘Institut Universitaire de France’ in 2015 and 2016, and President of one HCERES evaluation committee in 2017. His research programme on the archeogenomics of horse domestication has been awarded an ERC Consolidator Grant in 2015 (PEGASUS 681605).

Selected Invited Seminars [10/120, see here for a full list, Invited Seminars]
- November 4th 2018. AGTA Keynote Speaker. Adelaide, Australia.
- July 3rd 2018. JOBIM Keynote Speaker. Marseille, France.
- April 18th 2018. 1st AsiaEvo Keynote Speaker. Shenzen, China.
- March 15th 2018. Symposium of Gene Regulation in Evolution : From Molecular to Extended Phenotype. Mainz, Germany.
- February 16th 2018. Ancient DNA techniques for zoonosis research, Guest Speaker. Berlin, Germany.
- February 2nd 2018.Workshop on Population and Speciation Genomics, Keynote Speaker. Cesky Krumlov, Czech Republic.
- January 17th 2018. Department of Genetics, Univ. of Florida, Gainesville, USA.
- July 16th 2017. ISAG Keynote Speaker. Dublin, Ireland.
- May 17th 2017. YRLS Keynote Speaker. Paris, France.
- March 10th 2017. Illumina User Group Meeting, Keynote Speaker. Stockholm, Sweden. The genomic history of horse domestication.

Selected Publications [10/150 Peer-Reviewed, see here for a full list PeerReviewed]
- Gaunitz C, Fages A, Hanghøj K, Albrechtsen A, Khan N, Schubert M, Seguin-Orlando A, Owens IJ, Felkel S, Bignon-Lau O, de Barros Damgaard P, Mittnik A, Mohaseb AF, Davoudi H, Alquraishi S, Alfarhan AH, Al-Rasheid KAS, Crubézy E, Benecke N, Olsen S, Brown D, Anthony D, Massy K, Pitulko V, Kasparov A, Brem G, Hofreiter M, Mukhtarova G, Baimukhanov N, Lõugas L, Onar V, Stockhammer PW, Krause J, Boldgiv B, Undrakhbold S, Erdenebaatar D, Lepetz S, Mashkour M, Ludwig A, Wallner B, Merz V, Merz I, Zaibert V, Willerslev E, Librado P, Outram AK, Orlando L. Ancient genomes revisit the ancestry of domestic and Przewalski’s horses. 2018. Science Feb 22. pii : eaao3297. doi : 10.1126/science.aao3297.
- Sikora M, Seguin-Orlando A, Sousa VC, Albrechtsen A, Korneliussen T, Ko A, Rasmussen S, Dupanloup I, Nigst PR, Bosch MD, Renaud G, Allentoft ME, Margaryan A, Vasilyev SV, Veselovskaya EV, Borutskaya SB, Deviese T, Comeskey D, Higham T, Manica A, Foley R, Meltzer DJ, Nielsen R, Excoffier L, Lahr MM, Orlando L, Willerslev E. 2017. Science. Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers. Science 358:659-62.
- Librado P, Gamba C, Gaunitz C, Der Sarkissian C, Pruvost M, Albrechtsen A, Fages A, Khan N, Schubert M, Jagannathan V, Serres A, Kuderna LFK, Povolotskaya I, Seguin-Orlando A, Lepetz S, Neuditschko M, Theves C, Alquaraishi S, Alfarhan AH, Al-Rasheid K, Rieder S, Samashev Z, Francfort HP, Benecke N, Hofreiter M, Ludwig A, Keyser C, Marques-Bonet T, Ludes B, Crubezy E, Leeb T, Willerslev E, Orlando L. 2017. Ancient genomic changes associated with domestication of the horse. Science 356:442-5.
- Leonardi M, Librado P, Der Sarkissian C, Schubert M, Alfarhan AH, Alquraishi SA, Al-Rasheid KAS, Gamba C, Willerslev E, Orlando L. 2017. Evolutionary patterns and processes : lessons from ancient DNA. Syst Biol 66:e1-e29.
- Librado P, Fages A, Gaunitz C, Leonardi M, Wagner S, Khan N, Hanghøj K, Alquraishi SA, Alfarhan AH, Al-Rasheid KA, Der Sarkissian C, Schubert M, Orlando L. 2016. The Evolutionary Origin and Genetic Makeup of Domestic Horses. Genetics, 204:423-434.
- Librado P, Der Sarkissian C, Ermini L, Schubert M, Jónsson H, Albrechtsen A, Fumagalli M, Yang MA, Gamba C, Seguin-Orlando A, Mortensen CD, Petersen B, Hoover CA, Lorente-Galdos B, Nedoluzhko A, Boulygina E, Tsygankova S, Neuditschko M, Jagannathan V, Thèves C, Alfarhan AH, Alquraishi SA, Al-Rasheid KAS, Sicheritz-Ponten T, Popov R, Grigoriev S, Alekseev AN, Rubin EM, McCue M, Rieder S, Leeb T, Tikhonov A, Crubézy E, Slatkin MW, Marques-Bonet T, Nielsen R, Willerslev E, Kantanen J, Prokhortchouk E, Orlando L. 2015. Tracking the origins of Yakutian horses and the genetic basis for their fast adaptation to subarctic environments. Proc Natl Acad Sci U S A 112:E6889-97.
- Der Sarkissian C, Ermini L, Schubert M, Yang MA, Librado P, Fumagalli M, Jonsson H, Bar-Gal GK, Albrechtsen A, Vieira FG, Petersen B, Ginolhac A, Seguin-Orlando A, Magnussen K, Fages A, Gamba C, Lorente-Galdos B, Polani S, Steiner C, Neuditschko M, Jagannathan V, Feh C, Greenblat CL, Ludwig A, Abramson NI, Zimmermann W, Schafberg R, Tikhonov A, Sicheritz-Ponten T, Willerslev E, Marques-Bonet T, Ryder OA, McCue M, Rieder S, Leeb T, Slatkin M, Orlando L. 2015. Evolutionary genomics and conservation of the endangered Przewalski’s horse. Curr Biol 25:2577-83.
- Schubert M, Jónsson H, Chang D, Der Sarkissian C, Ermini L, Ginolhac A, Albrechtsen, Dupanloup I, Foucal A, Petersen B, Fumagalli M, Raghavan M, Seguin-Orlando A, Korneliussen T, Velazquez AMV, Stenderup J, Hoover CA, Rubin CJ, Alfarhan AH, Alqurqishi SA, Al-Rasheid KAS, MacHugh DE, Kalbfleisch T, MacLeod JN, Rubin EM, Sicheritz-Ponten T, Andersson L, Hofreiter M, Marques-Bonet T, Gilbert MTP, Nielsen R, Excoffier L, Willerslev L, Shapiro B, Orlando L. 2014. Prehistoric genomes reveal the genetic foundation and cost of horse domestication. Proc Natl Acad Sci U S A 111:E5661-9.
- Pedersen JS, Valen E, Vargas Velazques AM, Parker BJ, Rasmussen M, Lindgreen S, Lilje B, Tobin DJ, Kelly TK, Vang S, Andersson R, Jones PA, Hoover CA, Tikhonov A, Prokhortchouk E, Rubin EM, Sandelin A, Gilbert MT, Krogh A, Willerslev E, Orlando L. 2014. Genome-wide nucleosome map and cytosine methylation levels of an ancient human genome. Genome Res 24:454-66.
- Orlando L, Ginolhac A, Zhang G, Froese D, Albrechtsen A, Stiller M, Schubert M, Cappellini E, Petersen B, Moltke I, Johnson PL, Fumagalli M, Vilstrup JT, Raghavan M, Korneliussen T, Malaspinas AS, Vogt J, Szklarczyk D, Kelstrup CD, Vinther J, Dolocan A, Stenderup J, Velazquez AM, Cahill J, Rasmussen M, Wang X, Min J, Zazula GD, Seguin-Orlando A, Mortensen C, Magnussen K, Thompson JF, Weinstock J, Gregersen K, Røed KH, Eisenmann V, Rubin CJ, Miller DC, Antczak DF, Bertelsen MF, Brunak S, Al-Rasheid KA, Ryder O, Andersson L, Mundy J, Krogh A, Gilbert MT, Kjær K, Sicheritz-Ponten T, Jensen LJ, Olsen JV, Hofreiter M, Nielsen R, Shapiro B, Wang J, Willerslev E. 2013. Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse. Nature 499:74-8.

Peer-Reviewed list :

Invited Seminars :

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