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Paleogenetic and paleogenomic labs

par catherine Theves - publié le , mis à jour le

Paleogenetic and paleogenomic labs

Two laboratories are dedicated to the studies of ancient DNA (human and microbes) in controlled environment under positive pressure.

The staff

The team dedicated to the work of paleogenetic, palaeogenomics and paleoprotéomic includes two CNRS researchers (DR2 and CR1), a CNRS research engineer (IR2), and two Université Paul Sabatier technicians (TCH CN). Currently, two PhD students are involved in ongoing projects, (Doctoral School Biology Biotechnology Health, Toulouse) and a master 2 for each academic year.
Since 2012, the team is working to develop high-throughput sequencing studies (and more conventional paleogenetic studies) on old samples, via the controlled premises and equipment applied in the laboratory located at the Faculty of Medecine, 37 allées jules Guesde in partnership with platforms sequencing and bioinformatics in place of Toulouse. The establishment and early results are acquired and will soon publications on this topic.
The Toulouse site has new premises and laboratories (delivered in late 2013 and early 2014) for the team working on paleogenetics and palaeogenomics on the Faculty of Medicine, 37 allées Guesde.
Ancient DNA laboratory is composed of two facilities divided into 4 areas : an input SAS, a technical room, an extraction room and a pre-PCR and library preparation room.

The different areas dedicated new laboratory Paleogenetics ( Building A). 1 : the technical room of sample preparation ; 2 : cleaning the samples under controlled conditions ; 3 : the room of extraction ; 4 : pre -PCR room.

The sample degradation state requires significant precautions avoid contamination by modern DNA which would distort the results of experiments. For this purpose, it is essential to work in a "clean room" controlled environment with specific PPE. A second laboratory under controlled environment type P2, dedicated to the ancient pathogen study has been operational since 2014 and is also built on 4 spaces.

Evolving : Planned extensions to the laboratory by the end of 2016